Carboxylic acids and derivatives
Avanti Polar Lipids CARBOXYLIC ACID 50 MG
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt) | 1403744-37-5
eMolecules 135995-35-6 | 4-Bromomethyl-2-phthalimido-pyridine | J & W PharmLab LLC | MFCD09701357 | 317.142 | C14H9BrN2O2 | 96.000 | BrCc1ccnc(c1)N1C(=O)c2ccccc2C1=O | 500mg | 452546133
4-Bromomethyl-2-phthalimido-pyridine | J & W PharmLab LLC | 135995-35-6 | MFCD09701357 | 317.142 | C14H9BrN2O2 | 96.000 | BrCc1ccnc(c1)N1C(=O)c2ccccc2C1=O | 500mg | 452546133
Matrix Scientific METHYL DIFLUOROACETATE-25G
Methyl difluoroacetate, 99%; 25g,C3H4F2O2, MFCD00039276, mw 110.06, [433-53-4]
Apexbio Technology LLC Rigosertib sodium salt 1225497-78-8 10mM (in 1mL DMSO)
Rigosertib sodium salt (CAS 1225497-78-8) is a selective inhibitor targeting Polo-like kinase 1 (PLK1) with reported IC50 approximately 9 nM The compound notably decreases proliferation of cancer cell lines demonstrating nanomolar IC50 values in HeLa (115 nM) and C33A (45 nM) cells whereas normal cells (e g BJ and Ect1/E6E7) remain largely unaffected At concentrations exceeding 0 5 M rigosertib robustly induces G2/M phase arrest in cancer cells without significant cell cycle disruption at lower doses Additionally in vivo studies suggest its potential as a radiosensitizer in cervical carcinoma research
Medchemexpress LLC Enalapril (maleate) | 76095-16-4 | 99.95% | 250 MG
Enalapril maleate, also known as MK-421 maleate, is the active metabolite of enalapril and functions as an angiotensin-converting enzyme (ACE) inhibitor. Enalapril is a prodrug that is rapidly metabolized in the liver to enalaprilat following oral administration. It is a potent, competitive inhibitor of ACE, which is responsible for converting angiotensin I to angiotensin II, a key regulator of blood pressure. Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure. This product is for research use only.
- Harmful if swallowed.
- Causes skin and serious eye irritation.
- May cause respiratory irritation.
- Avoid breathing dust, fume, gas, mist, vapors, or spray.
- Keep container tightly sealed in a cool, well-ventilated area, away from moisture and direct sunlight.
- Wear protective gloves, clothing, eye protection, and face protection.
Apexbio Technology LLC Timolol Maleate 26921-17-5 10mM (in 1mL DMSO)
Timolol Maleate (CAS 26921-17-5) is the maleate salt form of the (S)-enantiomer of Timolol a potent non-selective -adrenergic receptor antagonist It exhibits high binding affinity toward both 1 and 2 adrenergic receptor subtypes with reported Ki values of approximately 1 97 nM ( 1) and 2 0 nM ( 2) Timolol maleate functions by competitively blocking adrenergic signaling pathways thus modulating sympathetic nervous system activities It is widely utilized in biomedical research to investigate -adrenergic signal transduction mechanisms and associated physiological processes including cardiac function and ophthalmic conditions
Cayman Chemical FluoresceIn dIacetate 5g
A cell-permeable fluorogenic cell viability probe; cleaved by intracellular esterases to produce fluorescein which displays excitation/emission maxima of 490/520 nm, respectively
Apexbio Technology LLC CA-074 Me 147859-80-1 10mg
CA-074 Me (CAS 147859-80-1) is a cell-permeable methyl ester derivative of CA-074 functioning primarily as a selective inhibitor of cathepsin B It exhibits potent inhibitory activity against cathepsin B (IC50 36 3 nM) In cultured human gingival fibroblasts CA-074 Me effectively suppresses cathepsin B activity while moderately reducing combined cathepsin B and L activities Under strong reducing conditions (e g presence of DTT or GSH) CA-074 Me inhibits cathepsin L substantially Thus it is widely utilized in biomedical research to study lysosomal enzyme functions and roles of cathepsins in cellular processes
Medchemexpress LLC AZD9496 maleate | 1639042-28-6 | 99.4% | 50 MG
AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with an IC50 of 0.28 nM. It functions as an orally bioavailable selective estrogen receptor degrader (SERD), identified as a laboratory chemical.
- Potent and selective estrogen receptor (ERα) antagonist
- Orally bioavailable selective estrogen receptor degrader (SERD)
- Suitable for scientific research
- Used in signaling pathways
- For research use only
Medchemexpress LLC BET bromodomain inhibitor 1 | 2411226-02-1 | 99.7% | 100 MG
BET bromodomain inhibitor 1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2.6 nM for BRD4. It binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (Kd values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, 2.1 nM, respectively). This inhibitor demonstrates anti-cancer activity.
- Orally active, selective BET bromodomain inhibitor
- High affinity binding to BRD proteins (BRD2(2), BRD3(2), BRD4(1), BRD4(2), BRDT(2))
- Demonstrates anti-cancer activity
- Excellent selectivity for BET bromodomain family
- Does not inhibit five cytochrome P450 enzymes
- Inhibits growth of acute myeloid leukemia and multiple myeloma cell lines
- Exhibits strong antitumor activities in vivo
- Induces G1-phase cell cycle arrest
- Dose-dependent inhibition of c-Myc and upregulation of p21
Medchemexpress LLC POPG (sodium salt) | 268550-95-4 | 99.2% | 1 ML
POPG sodium salt is a negatively charged phospholipid that influences the interactions of membrane proteins with other molecules by altering the charge characteristics of the lipid environment. It increases the apparent affinity of Gαq and Gβ1γ1 for activated NTS1 and can interact with the positive charge of peptides. This product can be utilized in Parkinson's disease research and in the preparation of nanoparticles for co-encapsulating and releasing hydrophilic peptide compounds.
- A negatively charged phospholipid
- Influences membrane protein interactions
- Increases affinity for activated NTS1
- Interacts with positive charge of peptides
- Applicable in Parkinson's disease research
- Used in nanoparticle preparation
- Enhances binding of PAP248-286 peptide
Medchemexpress LLC EDTA disodium manga 250g
Disodium manganese EDTA is a biochemical reagent that can be used as a biological material or organic compound for life science related research